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https://hdl.handle.net/10316/113647
Título: | Vaginal Sheets with Thymbra capitata Essential Oil for the Treatment of Bacterial Vaginosis: Design, Characterization and In Vitro Evaluation of Efficacy and Safety | Autor: | Tomás, Mariana Sousa, Lúcia G. V. Oliveira, Ana Sofia Gomes, Carolina P. Palmeira-de-Oliveira, Ana Cavaleiro, Carlos Salgueiro, Lígia Cerca, Nuno Martinez-de-Oliveira, José Oliveira, Rita Palmeira de |
Palavras-chave: | vaginal infections; bacterial vaginosis; treatment; vaginal sheet; Thymbra capitata essential oil; Gardnerella several species (spp.) | Data: | 2-Abr-2023 | Editora: | MDPI | Projeto: | PTDC/BIA-MIC/28271/2017 POCI-01- 0145-FEDER-028271) UIDB/00709/2020 UIDP/00709/2020 |
Título da revista, periódico, livro ou evento: | Gels | Volume: | 9 | Número: | 4 | Resumo: | We aimed to incorporate Thymbra capitata essential oil (TCEO), a potent antimicrobial natural product against bacterial vaginosis (BV)-related bacteria, in a suitable drug delivery system. We used vaginal sheets as dosage form to promote immediate relief of the typical abundant vaginal discharge with unpleasant odour. Excipients were selected to promote the healthy vaginal environment reestablishment and bioadhesion of formulations, while the TCEO acts directly on BV pathogens. We characterized vaginal sheets with TCEO in regard to technological characterization, predictable in vivo performance, in vitro efficacy and safety. Vaginal sheet D.O (acid lactic buffer, gelatine, glycerine, chitosan coated with TCEO 1% w/w) presented a higher buffer capacity and ability to absorb vaginal fluid simulant (VFS) among all vaginal sheets with EO, showing one of the most promising bioadhesive profiles, an excellent flexibility and structure that allow it to be easily rolled for application. Vaginal sheet D.O with 0.32 µL/mL TCEO was able to significantly reduce the bacterial load of all in vitro tested Gardnerella species. Although vaginal sheet D.O presented toxicity at some concentrations, this product was developed for a short time period of treatment, so this toxicity can probably be limited or even reversed when the treatment ends. | URI: | https://hdl.handle.net/10316/113647 | ISSN: | 2310-2861 | DOI: | 10.3390/gels9040293 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Vaginal-Sheets-with-Thymbra-capitata-Essential-Oil-for-the-Treatment-of-Bacterial-Vaginosis-Design-Characterization-and-In-Vitro-Evaluation-of-Efficacy-and-SafetyGels.pdf | 1.87 MB | Adobe PDF | Ver/Abrir |
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