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https://hdl.handle.net/10316/114187
Título: | The impact of insomnia on frailty and the hallmarks of aging | Autor: | Carvalhas-Almeida, Catarina Cavadas, Cláudia Álvaro, Ana Rita |
Palavras-chave: | Frailty; Insomnia; Hallmarks of aging; Circadian rhythms; Sleep | Data: | Fev-2023 | Editora: | Springer Nature | Projeto: | European Union’s Horizon 2020 research and innovation program under Grant Agreement Nº 857524 and was financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme, under the project CENTRO-01–0145-FEDER-000012 (HealthyAging 2020); POCI-01–0145-FEDER-029002 (noOSAnoAGEING, PTDC/ MEC-MCI/29002/2017) UIDB/04539/2020 UIDP/04539/2020 LA/P/0058/2020 European Social Fund through POCH— Human Capital Operational Programme and Portuguese national funds via FCT under 2020.04499.BD |
Título da revista, periódico, livro ou evento: | Aging Clinical and Experimental Research | Volume: | 35 | Número: | 2 | Resumo: | Throughout the course of life, there are age-related changes in sleep. Despite these normal changes, there is a high percentage of older adults that report sleep dissatisfaction with a high pervasiveness of chronic insomnia, the most common sleep disorder worldwide, with its prevalence being expected to continuously increase due to the growing rates of aging and obesity. This can have different adverse health outcomes, especially by promoting both physical and cognitive decline, which ultimately may aggravate frailty in older adults. Moreover, age-related frailty and sleep dysfunction may have a common mechanism related to the hallmarks of cellular aging. Cellular aging was categorized into nine hallmarks, such as DNA damage, telomere attrition and epigenetic changes. In the context of geriatric and chronic insomnia research, this review aims at discussing the current evidence from both animal models and human cohorts addressing the link between chronic insomnia, the hallmarks of aging and their impact on frailty. Moreover, the most recent research about the putative effect of insomnia therapeutic approaches on hallmarks of aging will be also highlighted. | URI: | https://hdl.handle.net/10316/114187 | ISSN: | 1720-8319 | DOI: | 10.1007/s40520-022-02310-w | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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The-impact-of-insomnia-on-frailty-and-the-hallmarks-of-agingAging-Clinical-and-Experimental-Research.pdf | 1.1 MB | Adobe PDF | Ver/Abrir |
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