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https://hdl.handle.net/10316/12661
Título: | Caveolae as an additional route for influenza virus endocytosis in MDCK cells | Autor: | Nunes-Correia, Isabel Eulálio, Ana Nir, Shlomo Lima, Maria C. Pedroso de |
Palavras-chave: | Influenza Virus; MDCK Cells; Endocytosis; Clathrin; Caveolae | Data: | 2004 | Editora: | Polish Society for Cell Biology | Citação: | Cellular & Molecular Biology Letters. 9:1 (2004) 47-60 | Resumo: | Clathrin-mediated endocytosis has been described as the primary internalization pathway for many viruses, including the influenza virus. However, caveolae, an alternative clathrin-independent endocytotic pathway, has also been described as mediating the entry of some molecules, including viruses. To address the question of pathway selection by the influenza virus, we have investigated whether the virus is internalized via clathrin-coated pits and/or caveolae in Madin Darby canine kidney (MDCK) cells. By applying pharmacological manipulations to selectively disrupt the cell internalization pathways, we found that, in MDCK cells, the influenza virus may be internalized via caveolae in addition to entry by clathrin-mediated endocytosis. However, a small contribution by another mode of entry, as recently proposed, cannot be excluded | URI: | https://hdl.handle.net/10316/12661 | ISSN: | 1425-8153 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Caveolae as an additional route for influenza virus endocytosis.pdf | 91.61 kB | Adobe PDF | Ver/Abrir |
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