Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/27278
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Moura, Liane I. F. | - |
dc.contributor.author | Dias, Ana M. A. | - |
dc.contributor.author | Leal, Ermelindo C. | - |
dc.contributor.author | Carvalho, Lina | - |
dc.contributor.author | Sousa, Hermínio C. de | - |
dc.contributor.author | Carvalho, Eugénia | - |
dc.date.accessioned | 2014-10-15T09:29:32Z | - |
dc.date.available | 2014-10-15T09:29:32Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | MOURA, Liane I. F. [et. al] - Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing. "Acta Biomaterialia". ISSN 1742-7061. Vol. 10 Nº. 2 (2014) p. 843-857 | - |
dc.identifier.issn | 1742-7061 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/27278 | - |
dc.description.abstract | One important complication of diabetes mellitus is chronic, non-healing diabetic foot ulcers (DFUs). This study aims to develop and use dressings based on chitosan derivatives for the sustained delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. Three different derivatives, namely N-carboxymethyl chitosan, 5-methyl pyrrolidinone chitosan (MPC) and N-succinyl chitosan, are presented as potential biomaterials for wound healing applications. Our results show that MPC has the best fluid handling capacity and delivery profile, also being non-toxic to Raw 264.7 and HaCaT cells. NT-loaded and non-loaded MPC dressings were applied to control/diabetic wounds to evaluate their in vitro/in vivo performance. The results show that the former induced more rapid healing (50% wound area reduction) in the early phases of wound healing in diabetic mice. A NT-loaded MPC foam also reduced expression of the inflammatory cytokine TNF-α (P < 0.001) and decreased the amount of inflammatory infiltrate on day 3. On day 10 MMP-9 was reduced in diabetic skin (P < 0.001), significantly increasing fibroblast migration and collagen (COL1A1, COL1A2 and COL3A1) expression and deposition. These results suggest that MPC-based dressings may work as an effective support for sustained NT release to reduce DFUs. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.rights | openAccess | pt |
dc.subject | Chitosan derivatives | pt |
dc.subject | Wound dressings | pt |
dc.subject | Diabetic foot ulcers | pt |
dc.subject | Neurotensin | pt |
dc.subject | Wound healing | pt |
dc.title | Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing | pt |
dc.type | article | - |
degois.publication.firstPage | 843 | pt |
degois.publication.lastPage | 857 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | Acta Biomaterialia | pt |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1742706113005047 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.actbio.2013.09.040 | pt |
degois.publication.volume | 10 | pt |
dc.date.embargo | 2014-02-01 | * |
dc.date.periodoembargo | 0 | - |
dc.identifier.pmid | 24121197 | - |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB) | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-0865-0257 | - |
crisitem.author.orcid | 0000-0003-1748-9861 | - |
crisitem.author.orcid | 0000-0001-8349-4488 | - |
crisitem.author.orcid | 0000-0002-2629-7805 | - |
Aparece nas coleções: | I&D CERES - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FCTUC Eng.Química - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Chitosan-based dressings loaded with neurotensin-an efficient strategy.pdf | 1.01 MB | Adobe PDF | Ver/Abrir | |
1-s2.0-S1742706113005047-main.pdf | 3.18 MB | Unknown | Ver/Abrir |
Citações SCOPUSTM
134
Visto em 23/set/2024
Citações WEB OF SCIENCETM
1
116
Visto em 2/set/2024
Visualizações de página 20
735
Visto em 24/set/2024
Downloads 50
879
Visto em 24/set/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.