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https://hdl.handle.net/10316/27278
Título: | Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing | Autor: | Moura, Liane I. F. Dias, Ana M. A. Leal, Ermelindo C. Carvalho, Lina Sousa, Hermínio C. de Carvalho, Eugénia |
Palavras-chave: | Chitosan derivatives; Wound dressings; Diabetic foot ulcers; Neurotensin; Wound healing | Data: | Fev-2014 | Editora: | Elsevier | Citação: | MOURA, Liane I. F. [et. al] - Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing. "Acta Biomaterialia". ISSN 1742-7061. Vol. 10 Nº. 2 (2014) p. 843-857 | Título da revista, periódico, livro ou evento: | Acta Biomaterialia | Volume: | 10 | Número: | 2 | Resumo: | One important complication of diabetes mellitus is chronic, non-healing diabetic foot ulcers (DFUs). This study aims to develop and use dressings based on chitosan derivatives for the sustained delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. Three different derivatives, namely N-carboxymethyl chitosan, 5-methyl pyrrolidinone chitosan (MPC) and N-succinyl chitosan, are presented as potential biomaterials for wound healing applications. Our results show that MPC has the best fluid handling capacity and delivery profile, also being non-toxic to Raw 264.7 and HaCaT cells. NT-loaded and non-loaded MPC dressings were applied to control/diabetic wounds to evaluate their in vitro/in vivo performance. The results show that the former induced more rapid healing (50% wound area reduction) in the early phases of wound healing in diabetic mice. A NT-loaded MPC foam also reduced expression of the inflammatory cytokine TNF-α (P < 0.001) and decreased the amount of inflammatory infiltrate on day 3. On day 10 MMP-9 was reduced in diabetic skin (P < 0.001), significantly increasing fibroblast migration and collagen (COL1A1, COL1A2 and COL3A1) expression and deposition. These results suggest that MPC-based dressings may work as an effective support for sustained NT release to reduce DFUs. | URI: | https://hdl.handle.net/10316/27278 | ISSN: | 1742-7061 | DOI: | 10.1016/j.actbio.2013.09.040 | Direitos: | openAccess |
Aparece nas coleções: | I&D CERES - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FCTUC Eng.Química - Artigos em Revistas Internacionais |
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Chitosan-based dressings loaded with neurotensin-an efficient strategy.pdf | 1.01 MB | Adobe PDF | Ver/Abrir | |
1-s2.0-S1742706113005047-main.pdf | 3.18 MB | Unknown | Ver/Abrir |
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