Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/44674
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferreira, José Augusto | - |
dc.contributor.author | Grassi, M. | - |
dc.contributor.author | Gudin͂o, Elias | - |
dc.contributor.author | Oliveira, Paula de | - |
dc.date.accessioned | 2017-11-29T17:25:03Z | - |
dc.date.available | 2017-11-29T17:25:03Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://hdl.handle.net/10316/44674 | - |
dc.description.abstract | A three-dimensional mathematical model for sorption/desorption by a cylindrical polymeric matrix with dispersed drug is proposed. The model is based on a system of partial differential equations coupled with boundary conditions over a moving boundary. We assume that the penetrant diffuses into a swelling matrix and causes a deformation, which induces a stress-driven diffusion and consequently a non-Fickian mass flux. A physically sound nonlinear dependence between strain and penetrant concentration is considered and introduced in a Boltzmann integral with a kernel computed from a Maxwell--Wiechert model. Numerical simulations show how the mechanistic behavior can have a role in drug delivery design. | por |
dc.language.iso | eng | por |
dc.publisher | Society for Industrial and Applied Mathematics (SIAM) | por |
dc.relation | PEst-C/MAT/UI0324/2011 | por |
dc.rights | openAccess | por |
dc.title | A 3D Model for Mechanistic Control of Drug Release | por |
dc.type | article | - |
degois.publication.firstPage | 620 | por |
degois.publication.lastPage | 633 | por |
degois.publication.issue | 3 | por |
degois.publication.title | SIAM Journal on Applied Mathematics | por |
dc.relation.publisherversion | http://epubs.siam.org/doi/10.1137/130930674 | por |
dc.peerreviewed | yes | por |
dc.identifier.doi | 10.1137/130930674 | por |
dc.identifier.doi | 10.1137/130930674 | - |
degois.publication.volume | 74 | por |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CMUC - Centre for Mathematics of the University of Coimbra | - |
crisitem.author.researchunit | CMUC - Centre for Mathematics of the University of Coimbra | - |
crisitem.author.orcid | 0000-0002-5226-2905 | - |
crisitem.author.orcid | 0000-0001-6634-6651 | - |
Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
JAF_MG_EG_PO.pdf | 1.86 MB | Adobe PDF | View/Open |
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