Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4840
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Prata, M. I. M. | - |
dc.contributor.author | Santos, A. C. | - |
dc.contributor.author | Geraldes, C. F. G. C. | - |
dc.contributor.author | Lima, J. J. P. de | - |
dc.date.accessioned | 2008-09-01T14:15:22Z | - |
dc.date.available | 2008-09-01T14:15:22Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Journal of Inorganic Biochemistry. 79:1-4 (2000) 359-363 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/4840 | - |
dc.description.abstract | The solution chemistry and structure of the complex of the triazamacrocyclic ligand NOTP (1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate)) with Ga3+ in D2O have been investigated by 1H, 71Ga and 31P NMR spectroscopy. These NMR results show the presence of a 1:1 Ga(NOTP)3- complex, with a highly symmetrical, pseudo-octahedral geometry, possibly with a C3 axis. The 1H spectrum shows that the triazamacrocyclic chelate ring is very rigid, with all the ring protons non-equivalent. The complex is stable in aqueous solution in a wide pH range. Its high thermodynamic stability agrees well with previous results from biodistribution and [gamma] imaging studies in Wistar rats with 67Ga3+ chelates of triaza macrocyclic ligands, which showed that the neutral chelates 67Ga(NOTA) (where NOTA is 1,4,7-triazacyclononane-1,4,7-triacetate) and 67Ga(NOTPME) (where NOTPME is 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate monoethylester)) have similar in vivo behaviour, with high stability and rapid renal excretion, but the high negatively charged 67Ga(NOTP)3- has a considerably slower kidney uptake and elimination. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6TGG-40X8D8M-26/1/b0839261f5ddd424e05a2da9204295a2 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Gallium | en_US |
dc.subject | Triazamacrocycle | en_US |
dc.subject | Phosphonate | en_US |
dc.subject | Structure | en_US |
dc.subject | Biodistribution | en_US |
dc.title | Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/S0162-0134(99)00232-9 | - |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-2888-0073 | - |
crisitem.author.orcid | 0000-0002-0837-8329 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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file768985de685e4c3bb29ea7634c7dc1fd.pdf | 152.06 kB | Adobe PDF | View/Open |
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