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https://hdl.handle.net/10316/4840
Título: | Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging | Autor: | Prata, M. I. M. Santos, A. C. Geraldes, C. F. G. C. Lima, J. J. P. de |
Palavras-chave: | Gallium; Triazamacrocycle; Phosphonate; Structure; Biodistribution | Data: | 2000 | Citação: | Journal of Inorganic Biochemistry. 79:1-4 (2000) 359-363 | Resumo: | The solution chemistry and structure of the complex of the triazamacrocyclic ligand NOTP (1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate)) with Ga3+ in D2O have been investigated by 1H, 71Ga and 31P NMR spectroscopy. These NMR results show the presence of a 1:1 Ga(NOTP)3- complex, with a highly symmetrical, pseudo-octahedral geometry, possibly with a C3 axis. The 1H spectrum shows that the triazamacrocyclic chelate ring is very rigid, with all the ring protons non-equivalent. The complex is stable in aqueous solution in a wide pH range. Its high thermodynamic stability agrees well with previous results from biodistribution and [gamma] imaging studies in Wistar rats with 67Ga3+ chelates of triaza macrocyclic ligands, which showed that the neutral chelates 67Ga(NOTA) (where NOTA is 1,4,7-triazacyclononane-1,4,7-triacetate) and 67Ga(NOTPME) (where NOTPME is 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate monoethylester)) have similar in vivo behaviour, with high stability and rapid renal excretion, but the high negatively charged 67Ga(NOTP)3- has a considerably slower kidney uptake and elimination. | URI: | https://hdl.handle.net/10316/4840 | DOI: | 10.1016/S0162-0134(99)00232-9 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
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