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https://hdl.handle.net/10316/5311
Título: | Regulation of AMPA receptors and synaptic plasticity | Autor: | Santos, S. D. Carvalho, A. L. Caldeira, M. V. Duarte, C. B. |
Palavras-chave: | long-term potentiation; long-term depression; glutamate; receptor trafficking; receptor phosphorylation | Data: | 1-Set-2008 | Citação: | Neuroscience. In Press, Corrected Proof: | Resumo: | Neuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors. These receptors account for most fast responses at excitatory synapses of the CNS, and their activity is regulated by various signaling pathways which control the electrophysiological properties of AMPA receptors and their interaction with numerous intracellular regulatory proteins. AMPA receptor phosphorylation/dephosphorylation and interaction with other proteins control their recycling and localization to defined postsynaptic sites, thereby regulating the strength of the synapse. This review focuses on recent advances in the understanding of the molecular mechanisms of regulation of AMPA receptors, and the implications in synaptic plasticity. | URI: | https://hdl.handle.net/10316/5311 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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filee25b3b9bee774d48a3fbd4a5db704ba3.pdf | 523.14 kB | Adobe PDF | Ver/Abrir |
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