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Title: | Stimulation of Immunoreactive Insulin Release by Glucose in Rat Brain Synaptosomes | Authors: | Santos, Maria Pereira, Emilia Carvaho, Arsélio |
Issue Date: | 1999 | Citation: | Neurochemical Research. 24:1 (1999) 33-36 | Abstract: | The effect of glucose on the release of immunoreactive insulin (IRI) in synaptosomes isolated from rat brain was studied. In the absence of glucose synaptosomes release about 4% (0.77 µIU/mg protein) of total content. Glucose increases significantly the IRI released by synaptosomes. Addition of the glycolytic inhibitor iodoacetic acid (IAA), decreased the glucose-induced release of IRI by about 50%, suggesting that glucose metabolism is involved. The observation that glucose provides a concentration related signal for IRI release indicates that this synaptosomal preparation may be useful as a model for research on the mechanism of insulin release in brain. | URI: | https://hdl.handle.net/10316/7900 | DOI: | 10.1023/A:1020971812098 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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