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https://hdl.handle.net/10316/80879
Title: | 2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: photosensitization efficiency, subcellular localization and in vivo studies | Authors: | Laranjo, Mafalda Serra, Arménio C. Abrantes, Margarida Piñeiro, Marta Gonçalves, Ana C. Casalta-Lopes, João Carvalho, Lina Sarmento-Ribeiro, Ana B. Rocha-Gonsalves, António Botelho, Filomena |
Issue Date: | Feb-2013 | Volume: | 10 | Issue: | 1 | Abstract: | Photodynamic therapy (PDT) is a therapeutic modality capable of inducing cell death by oxidative stress through activation of a sensitizer by light. Aryl-porphyrin with hydroxyl groups are good photosensitizers and presence of bromine atoms can enhance the photodynamic activity through heavy atom effect. These facts and our previous work made pertinent to compare the photodynamic capacity of tetraaryl brominated porphyrin (TBr4) with the corresponding diaryl (BBr2) derivative. | URI: | https://hdl.handle.net/10316/80879 | ISSN: | 1873-1597 | DOI: | 10.1016/j.pdpdt.2012.05.003 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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