Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/93139
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Laranjo, Mafalda | - |
dc.contributor.author | Aguiar, Márcia Campos | - |
dc.contributor.author | Pereira, Nelson A. M. | - |
dc.contributor.author | Brites, Gonçalo | - |
dc.contributor.author | Nascimento, Bruno F. O. | - |
dc.contributor.author | Brito, Ana F. | - |
dc.contributor.author | Casalta-Lopes, João | - |
dc.contributor.author | Gonçalves, Ana Cristina | - |
dc.contributor.author | Sarmento-Ribeiro, Ana Bela | - |
dc.contributor.author | Piñeiro Gomez, Marta | - |
dc.contributor.author | Botelho, Maria Filomena | - |
dc.contributor.author | Melo, Teresa M. V. D. Pinho e | - |
dc.date.accessioned | 2021-02-16T13:00:00Z | - |
dc.date.available | 2021-02-16T13:00:00Z | - |
dc.date.issued | 2020-08-15 | - |
dc.identifier.issn | 02235234 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/93139 | - |
dc.description.abstract | The discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging-guided photodynamic therapy. In addition to the high activity as PDT agent and absence of cytotoxicity per se, this molecule showed the ideal photophysical and photochemical properties. In vivo studies using a A375 melanoma mouse model, proved the extraordinary properties of this chlorin as a luminescent probe and the ability to impair tumor growth, making image guided treatment and follow up a possibility. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier Masson | pt |
dc.relation | UIDB/00313/2020 | pt |
dc.relation | UID/NEU/04539/2019 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | UIDP/00313/2020 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Animal models | pt |
dc.subject | Bladder carcinoma | pt |
dc.subject | Luminescence imaging | pt |
dc.subject | Melanoma | pt |
dc.subject | Oesophageal carcinoma | pt |
dc.subject | Optical imaging | pt |
dc.subject | Photodynamic therapy | pt |
dc.subject | Photosensitizers | pt |
dc.subject | Pt(II) chlorins | pt |
dc.subject | Theranostics | pt |
dc.subject.mesh | Antineoplastic Agents | pt |
dc.subject.mesh | Cell Line, Tumor | pt |
dc.subject.mesh | Cell Proliferation | pt |
dc.subject.mesh | Coordination Complexes | pt |
dc.subject.mesh | Dose-Response Relationship, Drug | pt |
dc.subject.mesh | Drug Screening Assays, Antitumor | pt |
dc.subject.mesh | Esophageal Neoplasms | pt |
dc.subject.mesh | Fluorescent Dyes | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Melanoma | pt |
dc.subject.mesh | Molecular Structure | pt |
dc.subject.mesh | Platinum | pt |
dc.subject.mesh | Porphyrins | pt |
dc.subject.mesh | Structure-Activity Relationship | pt |
dc.subject.mesh | Urinary Bladder Neoplasms | pt |
dc.subject.mesh | Optical Imaging | pt |
dc.subject.mesh | Photochemotherapy | pt |
dc.title | Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer | pt |
dc.type | article | - |
degois.publication.firstPage | 112468 | pt |
degois.publication.title | European Journal of Medicinal Chemistry | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0223523420304396 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.ejmech.2020.112468 | pt |
degois.publication.volume | 200 | pt |
dc.date.embargo | 2022-08-15 | * |
uc.date.periodoEmbargo | 730 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.project.grantno | CNC. IBILI | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-0689-6007 | - |
crisitem.author.orcid | 0000-0002-1891-9010 | - |
crisitem.author.orcid | 0000-0003-1532-684X | - |
crisitem.author.orcid | 0000-0003-1470-4802 | - |
crisitem.author.orcid | 0000-0002-4142-4841 | - |
crisitem.author.orcid | 0000-0002-7460-3758 | - |
crisitem.author.orcid | 0000-0001-7202-1650 | - |
crisitem.author.orcid | 0000-0003-3256-4954 | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Laranjo2020EurJMedChem-proof.pdf | 2.04 MB | Adobe PDF | View/Open |
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