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https://hdl.handle.net/10316/93139
Título: | Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer | Autor: | Laranjo, Mafalda Aguiar, Márcia Campos Pereira, Nelson A. M. Brites, Gonçalo Nascimento, Bruno F. O. Brito, Ana F. Casalta-Lopes, João Gonçalves, Ana Cristina Sarmento-Ribeiro, Ana Bela Piñeiro Gomez, Marta Botelho, Maria Filomena Melo, Teresa M. V. D. Pinho e |
Palavras-chave: | Animal models; Bladder carcinoma; Luminescence imaging; Melanoma; Oesophageal carcinoma; Optical imaging; Photodynamic therapy; Photosensitizers; Pt(II) chlorins; Theranostics | Data: | 15-Ago-2020 | Editora: | Elsevier Masson | Projeto: | UIDB/00313/2020 UID/NEU/04539/2019 UIDB/04539/2020 UIDP/04539/2020 UIDP/00313/2020 |
Título da revista, periódico, livro ou evento: | European Journal of Medicinal Chemistry | Volume: | 200 | Resumo: | The discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging-guided photodynamic therapy. In addition to the high activity as PDT agent and absence of cytotoxicity per se, this molecule showed the ideal photophysical and photochemical properties. In vivo studies using a A375 melanoma mouse model, proved the extraordinary properties of this chlorin as a luminescent probe and the ability to impair tumor growth, making image guided treatment and follow up a possibility. | URI: | https://hdl.handle.net/10316/93139 | ISSN: | 02235234 | DOI: | 10.1016/j.ejmech.2020.112468 | Direitos: | embargoedAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
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Laranjo2020EurJMedChem-proof.pdf | 2.04 MB | Adobe PDF | Ver/Abrir |
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