Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/96281
Título: | Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterization | Autor: | Fernandes, Ana R. Sanchez-Lopez, Elena Santini, Antonello Santos, Tiago dos Garcia, Maria L. Silva, Amélia Maria Lopes Dias da Souto, Eliana B. |
Palavras-chave: | DABCO surfactants; Cationic nanoemulsions; Ocular administration; Quinuclidine surfactants; Triamcinolone acetonide | Data: | 18-Out-2021 | Editora: | MDPI | Projeto: | SFRH/BD/130555/2017 UIDB/04033/2020 UIDB/04469/2020 |
Título da revista, periódico, livro ou evento: | Nanomaterials | Volume: | 11 | Número: | 10 | Resumo: | Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration. | URI: | https://hdl.handle.net/10316/96281 | ISSN: | 2079-4991 | DOI: | 10.3390/nano11102758 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
nanomaterials-11-02758 (1).pdf | 7.73 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
10
Visto em 30/set/2024
Citações WEB OF SCIENCETM
9
Visto em 2/set/2024
Visualizações de página
145
Visto em 1/out/2024
Downloads
98
Visto em 1/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons