Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/96433
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vasconcelos-Ferreira, Ana | - |
dc.contributor.author | Carmo-Silva, Sara | - |
dc.contributor.author | Codêsso, José Miguel Antunes | - |
dc.contributor.author | Silva, Patrick Joel da | - |
dc.contributor.author | Martinez, Alberto Rolim Muro | - |
dc.contributor.author | França, Marcondes Cavalcante | - |
dc.contributor.author | Nóbrega, Clévio David Rodrigues | - |
dc.contributor.author | Almeida, Luís Pereira de | - |
dc.date.accessioned | 2021-11-19T11:11:54Z | - |
dc.date.available | 2021-11-19T11:11:54Z | - |
dc.date.issued | 2021-08-25 | - |
dc.identifier.issn | 0305-1846 | pt |
dc.identifier.issn | 1365-2990 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/96433 | - |
dc.description.abstract | Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is the most common autosomal dominantly-inherited ataxia worldwide and is characterised by the accumulation of mutant ataxin-3 (mutATXN3) in different brain regions, leading to neurodegeneration. Currently, there are no available treatments able to block disease progression. In this study, we investigated whether carbamazepine (CBZ) would activate autophagy and mitigate MJD pathology. | pt |
dc.description.sponsorship | Fundação para a Ciência e Tecnologia; RichardChin and Lily Lock Machado-Joseph DiseaseResearch Fund; American PortugueseBiomedical Research Fund (APBRF); NationalAtaxia Foundation (USA); European UnionH2020 program, GA No.643417; EU JointProgram - Neurodegenerative DiseaseResearch (JPND); Competitiveness FactorsOperational Program (COMPETE 2020); ERDFthrough the Regional Operational ProgramCenter 2020 | pt |
dc.language.iso | eng | pt |
dc.publisher | British Neuropathological Society; Wiley | pt |
dc.relation | CENTRO-01-0145-FEDER-000008 (BRAINHEALTH 2020) | pt |
dc.relation | UID/NEU/04539/2020 | pt |
dc.relation | CENTRO-01-0145-FEDER (ViraVector) CancelStem , POCI-01-0145-FEDER-032309 | pt |
dc.relation | PTDC/NEU-NMC/0084/2014 (CortaCAGs) | pt |
dc.relation | POCI-01-0145-FEDER-016719 (CortaCAGs) | pt |
dc.relation | POCI-01-0145-FEDER-029716 (SpreadSilencing) | pt |
dc.relation | POCI-01-0145-FEDER-016807 (Imagene) | pt |
dc.relation | POCI-01-0145-FEDER-016390 (CancelStem) | pt |
dc.relation | POCI-01-0145-FEDER-032309 (CancelStem ) | pt |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/643417/EU/ERA-NET for establishing synergies between the Joint Programming on Neurodegenerative Diseases Research and Horizon 2020 | pt |
dc.relation | SFRH/BD/87804/2012 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Machado-Joseph disease | pt |
dc.subject | Ataxin-3 | pt |
dc.subject | Autophagy | pt |
dc.subject | Carbamazepine | pt |
dc.subject | Neuroprotection | pt |
dc.title | The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease | pt |
dc.type | article | - |
degois.publication.title | Neuropathology and Applied Neurobiology | pt |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/epdf/10.1111/nan.12763 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1111/nan.12763 | pt |
dc.date.embargo | 2022-08-25 | * |
uc.date.periodoEmbargo | 365 | pt |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.orcid | 0000-0002-8968-0641 | - |
crisitem.author.orcid | 0000-0002-8312-5292 | - |
crisitem.author.orcid | 0000-0001-5831-3307 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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nan.12763.pdf | 3.48 MB | Adobe PDF | View/Open |
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